5UAV

Structure of human PYCR-1 complexed with NADPH and L-tetrahydrofuroic acid

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E	Pyrroline-5-carboxylate reductase 1, mitochondrial	polymer	322	34043.2	5	UniProt (P32322) Pfam (PF03807) Pfam (PF14748) In PDB	Homo sapiens (Human)	P5CR 1
2	A, B, C, D, E	NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		745.4	5	Chemie (NDP)
3	A, B, C, D, E	TETRAHYDROFURAN-2-CARBOXYLIC ACID	non-polymer		116.1	5	Chemie (TFB)
4	C	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	1	Chemie (PEG)
5		water	water		18.0	659	Chemie (HOH)

Sequence modifications

A, B, C, D, E: 1 - 300 (UniProt: P32322)

PDB	External Database	Details
Met -21	-	initiating methionine
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
Ser -14	-	expression tag
Ser -13	-	expression tag
Gly -12	-	expression tag
Val -11	-	expression tag
Asp -10	-	expression tag
Leu -9	-	expression tag
Gly -8	-	expression tag
Thr -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	170215.8
Non-Polymers*	Number of molecules	11
	Total formula weight	4413.8
All*	Total formula weight	174629.6

*Water molecules are not included.