5TQ3
Design and Synthesis of a pan-JAK kinase inhibitor clinical candidate (PF-06263276) suitable for the treatment of inflammatory diseases of the lungs and skin
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Tyrosine-protein kinase JAK2 | polymer | 304 | 35892.7 | 2 | UniProt (O60674) Pfam (PF07714) In PDB | Homo sapiens (Human) | Janus kinase 2,JAK-2 |
2 | A, B | 4-[3-(1H-benzimidazol-2-yl)-1H-indazol-6-yl]-3-ethylphenol | non-polymer | 354.4 | 2 | Chemie (7GZ) | |||
3 | water | water | 18.0 | 53 | Chemie (HOH) |
Sequence modifications
A, B: 837 - 1132 (UniProt: O60674)
PDB | External Database | Details |
---|---|---|
Met 829 | - | initiating methionine |
Gly 830 | - | expression tag |
His 831 | - | expression tag |
His 832 | - | expression tag |
His 833 | - | expression tag |
His 834 | - | expression tag |
His 835 | - | expression tag |
His 836 | - | expression tag |
Ser 1073 | Met 1073 | engineered mutation |
Thr 1076 | Phe 1076 | engineered mutation |
Val 1126 | Ile 1126 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 71785.3 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 708.8 | |
All* | Total formula weight | 72494.1 |