5TPS
Structure of a Fc heterodimer
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B | Ig gamma-1 chain C region | polymer | 243 | 27004.4 | 1 | UniProt (P01857) Pfam (PF07654) In PDB | Homo sapiens (Human) | |
2 | A | Ig gamma-1 chain C region | polymer | 232 | 25939.3 | 1 | UniProt (P01857) Pfam (PF07654) In PDB | Homo sapiens (Human) | |
3 | C | beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1276.2 | 1 | In PDB GlyTouCan (G28663KH) | |||
4 | D | beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1625.5 | 1 | In PDB GlyTouCan (G27919IH) | |||
5 | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
B: 221 - 447 (UniProt: P01857)
A: 221 - 447 (UniProt: P01857)
PDB | External Database | Details |
---|---|---|
Gly 216 | - | expression tag |
Ser 217 | - | expression tag |
Gly 218 | - | expression tag |
Gly 219 | - | expression tag |
Gly 220 | - | expression tag |
Cys 349 | Tyr 232 | engineered mutation |
Ser 366 | Thr 249 | engineered mutation |
Ala 368 | Leu 251 | engineered mutation |
Lys 405 | Phe 288 | engineered mutation |
Val 407 | Tyr 290 | engineered mutation |
Gly 448 | - | expression tag |
Gly 449 | - | expression tag |
Ser 450 | - | expression tag |
His 451 | - | expression tag |
His 452 | - | expression tag |
His 453 | - | expression tag |
His 454 | - | expression tag |
His 455 | - | expression tag |
His 456 | - | expression tag |
His 457 | - | expression tag |
His 458 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 216 | - | expression tag |
Ser 217 | - | expression tag |
Gly 218 | - | expression tag |
Gly 219 | - | expression tag |
Gly 220 | - | expression tag |
Cys 354 | Ser 237 | engineered mutation |
Trp 366 | Thr 249 | engineered mutation |
Ala 409 | Lys 292 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 52943.7 | |
Branched | Number of molecules | 2 |
Total formula weight | 2901.6 | |
All* | Total formula weight | 55845.4 |