5TOK

Crystal structure of the RSV F glycoprotein in complex with the neutralizing single-domain antibody F-VHH-L66

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C	Fusion glycoprotein F0, Fibritin chimera	polymer	550	61045.0	3	UniProt (P03420) Pfam (PF00523) In PDB	Human respiratory syncytial virus	Protein F
2	D, E, F	Single-domain antibody F-VHH-L66	polymer	131	14356.9	3		Lama glama (llama)
3	A, B, C	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	3	Chemie (NAG)
4	B	PHOSPHATE ION	non-polymer		95.0	1	Chemie (PO4)

Sequence modifications

A, B, C: 1 - 513 (UniProt: P03420)

PDB	External Database	Details
Ala 102	Pro 102	conflict
Cys 155	Ser 155	engineered mutation
Phe 190	Ser 190	engineered mutation
Leu 207	Val 207	engineered mutation
Cys 290	Ser 290	engineered mutation
Val 379	Ile 379	engineered mutation
Val 447	Met 447	engineered mutation

A, B, C: 514 - 550 (PDB: 5TOK)

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	226205.7
Non-Polymers*	Number of molecules	4
	Total formula weight	758.6
All*	Total formula weight	226964.3

*Water molecules are not included.