5TC6

Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with propylthio-immucillin-A

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	S-methyl-5'-thioadenosine phosphorylase	polymer	297	33119.1	1	UniProt (Q13126) Pfam (PF01048) In PDB	Homo sapiens (Human)	5'-methylthioadenosine phosphorylase,MTAPase
2	A	(2S,3S,4R,5S)-2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-[(propylsulfanyl)methyl]pyrrolidine-3,4-diol	non-polymer		323.4	1	Chemie (7A6)
3	A	PHOSPHATE ION	non-polymer		95.0	1	Chemie (PO4)
4	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
5	A	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
6	A	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
7		water	water		18.0	222	Chemie (HOH)

Sequence modifications

A: 1 - 283 (UniProt: Q13126)

PDB	External Database	Details
Met -13	-	initiating methionine
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	33119.1
Non-Polymers*	Number of molecules	5
	Total formula weight	568.9
All*	Total formula weight	33688.0

*Water molecules are not included.