5OYJ
Crystal structure of VEGFR-2 domains 4-5 in complex with DARPin D4b
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | DARPin D4b | polymer | 169 | 18339.4 | 2 | synthetic construct | ||
2 | C, D | Vascular endothelial growth factor receptor 2 | polymer | 234 | 26253.7 | 2 | UniProt (P35968) Pfam (PF07679) In PDB | Homo sapiens (Human) | VEGFR-2,Fetal liver kinase 1,FLK-1,Kinase insert domain receptor,KDR,Protein-tyrosine kinase receptor flk-1 |
3 | E, F, G, H, I... | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 7 | In PDB GlyTouCan (G42666HT) | |||
4 | L, M, N | alpha-D-glucopyranose-(1-1)-alpha-D-glucopyranose | branched | 342.3 | 3 | In PDB BIRD (PRD_900006) GlyTouCan (G92130SN) | trehalose | ||
5 | A, C | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
6 | A | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
7 | C | CACODYLATE ION | non-polymer | 137.0 | 1 | Chemie (CAC) | |||
8 | C | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
9 | water | water | 18.0 | 270 | Chemie (HOH) |
Sequence modifications
C, D: 326 - 549 (UniProt: P35968)
PDB | External Database | Details |
---|---|---|
Ala 322 | - | expression tag |
Pro 323 | - | expression tag |
Leu 324 | - | expression tag |
Ala 325 | - | expression tag |
His 550 | - | expression tag |
His 551 | - | expression tag |
His 552 | - | expression tag |
His 553 | - | expression tag |
His 554 | - | expression tag |
His 555 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 89186.3 | |
Branched | Number of molecules | 10 |
Total formula weight | 3997.7 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 379.3 | |
All* | Total formula weight | 93563.3 |