5NU5
Crystal structure of the human bromodomain of EP300 bound to the inhibitor XDM-CBP
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Histone acetyltransferase p300 | polymer | 116 | 13826.8 | 2 | UniProt (Q09472) Pfam (PF00439) In PDB | Homo sapiens (Human) | p300 HAT,E1A-associated protein p300 |
2 | A, B | ~{N}-[[2,8-bis(oxidanyl)naphthalen-1-yl]methyl]-4-ethanoyl-3-ethyl-5-methyl-1~{H}-pyrrole-2-carboxamide | non-polymer | 366.4 | 2 | Chemie (99E) | |||
3 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
4 | water | water | 18.0 | 345 | Chemie (HOH) |
Sequence modifications
A, B: 1048 - 1161 (UniProt: Q09472)
PDB | External Database | Details |
---|---|---|
Ser 1046 | - | expression tag |
Met 1047 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 27653.6 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 1043.2 | |
All* | Total formula weight | 28696.8 |