5MVD
Crystal structure of potent human Dihydroorotate Dehydrogenase inhibitors based on hydroxylated azole scaffolds
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Dihydroorotate dehydrogenase (quinone), mitochondrial | polymer | 363 | 39496.1 | 1 | UniProt (Q02127) Pfam (PF01180) In PDB | Homo sapiens (Human) | DHOdehase,Dihydroorotate oxidase |
| 2 | A | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 1 | Chemie (FMN) | |||
| 3 | A | OROTIC ACID | non-polymer | 156.1 | 1 | Chemie (ORO) | |||
| 4 | A | 1,5-dimethyl-3-oxidanyl-~{N}-[2,3,5,6-tetrakis(fluoranyl)-4-phenyl-phenyl]pyrazole-4-carboxamide | non-polymer | 379.3 | 1 | Chemie (U91) | |||
| 5 | A | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) | |||
| 6 | A | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 7 | water | water | 18.0 | 233 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 39496.1 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1216.2 | |
| All* | Total formula weight | 40712.3 |
