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5LCJ

In-Gel Activity-Based Protein Profiling of a Clickable Covalent Erk 1/2 Inhibitor

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AMitogen-activated protein kinase 1polymer36842551.91UniProt (P28482)
Pfam (PF00069)
In PDB
Homo sapiens (Human)MAPK 1,ERT1,Extracellular signal-regulated kinase 2,ERK-2,MAP kinase isoform p42,p42-MAPK,Mitogen-activated protein kinase 2,MAPK 2
2A[(1~{R},4~{Z})-cyclooct-4-en-1-yl] ~{N}-[4-[4-[[5-chloranyl-4-[[2-(propanoylamino)phenyl]amino]pyrimidin-2-yl]amino]pyridin-2-yl]but-3-ynyl]carbamatenon-polymer588.11Chemie (6TS)
3ASULFATE IONnon-polymer96.12Chemie (SO4)
4waterwater18.0535Chemie (HOH)
Sequence modifications
A: 1 - 360 (UniProt: P28482)
PDBExternal DatabaseDetails
Met -7-initiating methionine
Ala -6-expression tag
His -5-expression tag
His -4-expression tag
His -3-expression tag
His -2-expression tag
His -1-expression tag
His 0-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight42551.9
Non-Polymers*Number of molecules3
Total formula weight780.2
All*Total formula weight43332.1
*Water molecules are not included.

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PDB entries from 2024-06-12

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