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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

5L9U

Model of human Anaphase-promoting complex/Cyclosome (APC/C-CDH1) with a cross linked Ubiquitin variant-substrate-UBE2C (UBCH10) complex representing key features of multiubiquitination

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AAnaphase-promoting complex subunit 1polymer1944216725.51UniProt (Q9H1A4)
Pfam (PF12859)
Pfam (PF20518)
Pfam (PF21282)
Pfam (PF18122)
In PDB		Homo sapiens (Human)APC1,Cyclosome subunit 1,Mitotic checkpoint regulator,Testis-specific gene 24 protein
2BAnaphase-promoting complex subunit 11polymer849854.61UniProt (Q9NYG5)
Pfam (PF12861)
In PDB		Homo sapiens (Human)APC11,Cyclosome subunit 11,Hepatocellular carcinoma-associated RING finger protein
3C, PCell division cycle protein 23 homologpolymer59768921.02UniProt (Q9UJX2)
Pfam (PF04049)
In PDB		Homo sapiens (Human)Anaphase-promoting complex subunit 8,APC8,Cyclosome subunit 8
4DAnaphase-promoting complex subunit 15polymer12114286.71UniProt (P60006)
Pfam (PF15243)
In PDB		Homo sapiens (Human)APC15
5EAnaphase-promoting complex subunit 16polymer11011678.01UniProt (Q96DE5)
Pfam (PF17256)
In PDB		Homo sapiens (Human)APC16,Cyclosome subunit 16
6F, HCell division cycle protein 27 homologpolymer82491973.12UniProt (P30260)
Pfam (PF12895)
Pfam (PF00515)
In PDB		Homo sapiens (Human)Anaphase-promoting complex subunit 3,APC3,CDC27 homolog,CDC27Hs,H-NUC
7G, WAnaphase-promoting complex subunit CDC26polymer859794.02UniProt (Q8NHZ8)
Pfam (PF10471)
In PDB		Homo sapiens (Human)Anaphase-promoting complex subunit 12,APC12,Cell division cycle protein 26 homolog
8IAnaphase-promoting complex subunit 4polymer81893207.31UniProt (Q9UJX5)
Pfam (PF12894)
Pfam (PF12896)
In PDB		Homo sapiens (Human)APC4,Cyclosome subunit 4
9J, KCell division cycle protein 16 homologpolymer62071747.52UniProt (Q13042)
Pfam (PF12895)
Pfam (PF13424)
In PDB		Homo sapiens (Human)Anaphase-promoting complex subunit 6,APC6,CDC16 homolog,CDC16Hs,Cyclosome subunit 6
10LAnaphase-promoting complex subunit 10polymer18521282.11UniProt (Q9UM13)
Pfam (PF03256)
In PDB		Homo sapiens (Human)APC10,Cyclosome subunit 10
11MAnaphase-promoting complex subunit 13polymer748528.31UniProt (Q9BS18)
Pfam (PF05839)
In PDB		Homo sapiens (Human)APC13,Cyclosome subunit 13
12NAnaphase-promoting complex subunit 2polymer82293939.01UniProt (Q9UJX6)
Pfam (PF00888)
Pfam (PF08672)
In PDB		Homo sapiens (Human)APC2,Cyclosome subunit 2
13OAnaphase-promoting complex subunit 5polymer75585179.81UniProt (Q9UJX4)
Pfam (PF21371)
Pfam (PF12862)
In PDB		Homo sapiens (Human)APC5,Cyclosome subunit 5
14RFizzy-related protein homologpolymer49354838.71UniProt (Q9UM11)
Pfam (PF12894)
Pfam (PF00400)
In PDB		Homo sapiens (Human)Fzr,CDC20-like protein 1,Cdh1/Hct1 homolog,hCDH1
15SHsl1(substrate)_peptide-Ubiquitin_variant fusionpolymer15717057.31UniProt (P34244)
UniProt (Q63429)
Pfam (PF00240)
In PDB		Saccharomyces cerevisiae
16UUbiquitin-conjugating enzyme E2 Cpolymer18820768.31UniProt (O00762)
Pfam (PF00179)
In PDB		Homo sapiens (Human)(E3-independent) E2 ubiquitin-conjugating enzyme C,E2 ubiquitin-conjugating enzyme C,UbcH10,Ubiquitin carrier protein C,Ubiquitin-protein ligase C
17X, YAnaphase-promoting complex subunit 7polymer56563204.02UniProt (Q9UJX3)
Pfam (PF13181)
In PDB		Homo sapiens (Human)APC7,Cyclosome subunit 7
Sequence modifications
I: 1 - 808 (UniProt: Q9UJX5)
PDBExternal DatabaseDetails
Gly 809-expression tag
Gly 810-expression tag
Ser 811-expression tag
Leu 812-expression tag
Glu 813-expression tag
Val 814-expression tag
Leu 815-expression tag
Phe 816-expression tag
Gln 817-expression tag
Gly 818-expression tag
S: 743 - 759 (PDB: 5L9U)
PDBExternal DatabaseDetails
Gly 760-linker
Ser 761-linker
Gly 762-linker
Ser 763-linker
Gly 764-linker
Ser 765-linker
Gly 766-linker
Ser 767-linker
S: 768 - 842 (UniProt: P34244)
PDBExternal DatabaseDetails
-Lys 788deletion
-Asn 789deletion
-Gln 790deletion
-Phe 791deletion
-Asn 792deletion
-Met 793deletion
-Ser 794deletion
-Tyr 795deletion
-Lys 796deletion
-Pro 797deletion
-Ser 798deletion
-Glu 799deletion
-Asn 800deletion
-Met 801deletion
-Ser 802deletion
-Gly 803deletion
-Leu 804deletion
-Ser 805deletion
-Ser 806deletion
-Phe 807deletion
-Pro 808deletion
-Ile 809deletion
-Phe 810deletion
-Glu 811deletion
-Lys 812deletion
-Glu 813deletion
-Asn 814deletion
-Thr 815deletion
-Leu 816deletion
-Ser 817deletion
-Ser 818deletion
Cys 819Ser 819engineered mutation
Ser 843-linker
Gly 844-linker
Ser 845-linker
Ser 846-linker
Gly 847-linker
Ser 848-linker
Gly 849-linker
Ser 850-linker
Ser 851-linker
Gly 852-linker
S: 853 - 930 (UniProt: Q63429)
PDBExternal DatabaseDetails
Leu 856Phe 4engineered mutation
Pro 860Leu 8engineered mutation
Arg 861Thr 9engineered mutation
Ile 894Arg 42engineered mutation
Phe 896Ile 44engineered mutation
Val 899Gly 47engineered mutation
Arg 901Gln 49engineered mutation
Lys 916Glu 64engineered mutation
Ser 918Thr 66engineered mutation
Leu 920His 68engineered mutation
Ala 922Val 70engineered mutation
Met 923Leu 71engineered mutation
Val 925Leu 73engineered mutation
Pro 926Arg 74engineered mutation
Lys 928Gly 76engineered mutation
Lys 930Gln 78engineered mutation
U: 1 - 179 (UniProt: O00762)
PDBExternal DatabaseDetails
Sec -1-expression tag
Asx 0-expression tag
Ala 102Cys 102engineered mutation
Trp 180-expression tag
Ser 181-expression tag
His 182-expression tag
Pro 183-expression tag
Gln 184-expression tag
Glu 185-expression tag
Lys 186-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains22
Total formula weight1258625.0
All*Total formula weight1258625.0
*Water molecules are not included.

218853

PDB entries from 2024-04-24

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