5L9B
HIF PROLYL HYDROXYLASE 2 (PHD2/ EGLN1) IN COMPLEX WITH 2-OXOGLUTARATE (2OG) AND HIF-1ALPHA CODD (556-574)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Egl nine homolog 1 | polymer | 252 | 27978.8 | 2 | UniProt (Q9GZT9) Pfam (PF13640) In PDB | Homo sapiens (Human) | Hypoxia-inducible factor prolyl hydroxylase 2,HPH-2,Prolyl hydroxylase domain-containing protein 2,PHD2,SM-20 |
| 2 | C, D | Hypoxia-inducible factor 1-alpha | polymer | 19 | 2254.5 | 2 | UniProt (Q16665) Pfam (PF11413) In PDB | Homo sapiens | HIF1-alpha,ARNT-interacting protein,Basic-helix-loop-helix-PAS protein MOP1,Class E basic helix-loop-helix protein 78,bHLHe78,Member of PAS protein 1,PAS domain-containing protein 8 |
| 3 | A, B | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) | |||
| 4 | A, B | 2-OXOGLUTARIC ACID | non-polymer | 146.1 | 2 | Chemie (AKG) | |||
| 5 | water | water | 18.0 | 298 | Chemie (HOH) |
Sequence modifications
A, B: 181 - 426 (UniProt: Q9GZT9)
| PDB | External Database | Details |
|---|---|---|
| Gly 175 | - | expression tag |
| Ser 176 | - | expression tag |
| His 177 | - | expression tag |
| Met 178 | - | expression tag |
| Ala 179 | - | expression tag |
| Ser 180 | - | expression tag |
| Ala 201 | Cys 201 | engineered mutation |
| Ala 398 | Arg 398 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 60466.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 402.1 | |
| All* | Total formula weight | 60868.7 |
