5L7W
17beta-hydroxysteroid dehydrogenase 14 variant T205 in complex with a non-steroidal inhibitor.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | 17-beta-hydroxysteroid dehydrogenase 14 | polymer | 274 | 28682.7 | 1 | UniProt (Q9BPX1) Pfam (PF13561) In PDB | Homo sapiens (Human) | 17-beta-HSD 14,17-beta-hydroxysteroid dehydrogenase DHRS10,Dehydrogenase/reductase SDR family member 10,Retinal short-chain dehydrogenase/reductase retSDR3,Short chain dehydrogenase/reductase family 47C member 1 |
| 2 | A | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 1 | Chemie (NAD) | |||
| 3 | A | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 4 | A | [4-fluoranyl-2,3-bis(oxidanyl)phenyl]-[6-(2-fluoranyl-3-oxidanyl-phenyl)pyridin-2-yl]methanone | non-polymer | 343.3 | 1 | Chemie (6QU) | |||
| 5 | A | beta-D-glucopyranose | non-polymer | 180.2 | 1 | Chemie (BGC) | |||
| 6 | water | water | 18.0 | 204 | Chemie (HOH) |
Sequence modifications
A: 1 - 270 (UniProt: Q9BPX1)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| His 0 | - | expression tag |
| Gly 271 | - | expression tag |
| Ser 272 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 28682.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1209.9 | |
| All* | Total formula weight | 29892.6 |
