5KPD

Mouse pgp 34 linker deleted double EQ mutant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Multidrug resistance protein 1A	polymer	1248	137793.3	2	UniProt (P21447) Pfam (PF00664) Pfam (PF00005) In PDB	Mus musculus (Mouse)	ATP-binding cassette sub-family B member 1A,MDR1A,Multidrug resistance protein 3,P-glycoprotein 3

Sequence modifications

A, B: 1 - 1276 (UniProt: P21447)

PDB	External Database	Details
Gln 552	Glu 552	engineered mutation
-	Met 649	deletion
-	Ser 650	deletion
-	Ser 651	deletion
-	Lys 652	deletion
-	Asp 653	deletion
-	Ser 654	deletion
-	Gly 655	deletion
-	Ser 656	deletion
-	Ser 657	deletion
-	Leu 658	deletion
-	Ile 659	deletion
-	Arg 660	deletion
-	Arg 661	deletion
-	Arg 662	deletion
-	Ser 663	deletion
-	Thr 664	deletion
-	Arg 665	deletion
-	Lys 666	deletion
-	Ser 667	deletion
-	Ile 668	deletion
-	Cys 669	deletion
-	Gly 670	deletion
-	Pro 671	deletion
-	His 672	deletion
-	Asp 673	deletion
-	Gln 674	deletion
-	Asp 675	deletion
-	Arg 676	deletion
-	Lys 677	deletion
-	Leu 678	deletion
-	Ser 679	deletion
-	Thr 680	deletion
-	Lys 681	deletion
-	Glu 682	deletion
Gln 1197	Glu 1197	engineered mutation
His 1277	-	expression tag
His 1278	-	expression tag
His 1279	-	expression tag
His 1280	-	expression tag
His 1281	-	expression tag
His 1282	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	275586.7
All*	Total formula weight	275586.7

*Water molecules are not included.