5K7L

Single particle cryo-EM structure of the voltage-gated K+ channel Eag1 bound to the channel inhibitor calmodulin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Potassium voltage-gated channel subfamily H member 1	polymer	857	97359.8	1	UniProt (Q63472) Pfam (PF13426) Pfam (PF00520) Pfam (PF00027) In PDB	Rattus norvegicus (Rat)	Voltage-gated potassium channel Eag1, Ether-a-go-go potassium channel 1, r-eag, Voltage-gated potassium channel subunit Kv10.1
2	B	Calmodulin	polymer	149	16852.5	1	UniProt (P62158) Pfam (PF13499) UniProt (by SIFTS) (P0DP23) In PDB	Homo sapiens (Human)	CaM
3	A	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
4	A	CHOLESTEROL HEMISUCCINATE	non-polymer		486.7	1	Chemie (Y01)

Sequence modifications

A: 1 - 773 (UniProt: Q63472)
A: 774 - 848 (UniProt: Q63472)

PDB	External Database	Details
Ser 849	-	expression tag
Asn 850	-	expression tag
Ser 851	-	expression tag
Leu 852	-	expression tag
Glu 853	-	expression tag
Val 854	-	expression tag
Leu 855	-	expression tag
Phe 856	-	expression tag
Gln 857	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	114212.3
Non-Polymers*	Number of molecules	2
	Total formula weight	707.9
All*	Total formula weight	114920.2

*Water molecules are not included.