5JAO
Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered Through X-Ray Fragment Screening
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Platelet-activating factor acetylhydrolase | polymer | 388 | 44203.1 | 1 | UniProt (Q13093) Pfam (PF03403) In PDB | Homo sapiens (Human) | PAF acetylhydrolase,1-alkyl-2-acetylglycerophosphocholine esterase,2-acetyl-1-alkylglycerophosphocholine esterase,Group-VIIA phospholipase A2,gVIIA-PLA2,LDL-associated phospholipase A2,LDL-PLA(2),PAF 2-acylhydrolase |
2 | A | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
3 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
4 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
5 | A | 2'-chloro-6-methyl[1,1'-biphenyl]-3-amine | non-polymer | 217.7 | 1 | Chemie (6HX) | |||
6 | water | water | 18.0 | 545 | Chemie (HOH) |
Sequence modifications
A: 46 - 428 (UniProt: Q13093)
PDB | External Database | Details |
---|---|---|
His 429 | - | expression tag |
His 430 | - | expression tag |
His 431 | - | expression tag |
His 432 | - | expression tag |
His 433 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 44203.1 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 371.4 | |
All* | Total formula weight | 44574.5 |