5I86
Crystal structure of the bromodomain of human CREBBP bound to the benzodiazepinone G02778174
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | CREB-binding protein | polymer | 118 | 13992.0 | 2 | UniProt (Q92793) Pfam (PF00439) In PDB | Homo sapiens (Human) | |
| 2 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 3 | A | THIOCYANATE ION | non-polymer | 58.1 | 1 | Chemie (SCN) | |||
| 4 | A, B | (4R)-N-benzyl-4-methyl-2-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-6-carboxamide | non-polymer | 309.4 | 2 | Chemie (69A) | |||
| 5 | water | water | 18.0 | 385 | Chemie (HOH) |
Sequence modifications
A, B: 1082 - 1197 (UniProt: Q92793)
| PDB | External Database | Details |
|---|---|---|
| Gly 1080 | - | expression tag |
| Ser 1081 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 27984.0 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 800.9 | |
| All* | Total formula weight | 28785.0 |
