5H14
EED in complex with an allosteric PRC2 inhibitor EED666
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Polycomb protein EED | polymer | 367 | 42356.2 | 2 | UniProt (O75530) Pfam (PF00400) In PDB | Homo sapiens (Human) | hEED,WD protein associating with integrin cytoplasmic tails 1,WAIT-1 |
| 2 | C, D | Histone-lysine N-methyltransferase EZH2 | polymer | 29 | 3622.2 | 2 | UniProt (Q15910) Pfam (PF11616) In PDB | Homo sapiens | ENX-1,Enhancer of zeste homolog 2,Lysine N-methyltransferase 6 |
| 3 | A, B | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 4 | A, B | 2-[3-(3,5-dimethylpyrazol-1-yl)-4-nitro-phenyl]-3,4-dihydro-1H-isoquinoline | non-polymer | 348.4 | 2 | Chemie (LQB) | |||
| 5 | water | water | 18.0 | 412 | Chemie (HOH) |
Sequence modifications
A, B: 76 - 441 (UniProt: O75530)
| PDB | External Database | Details |
|---|---|---|
| Gly 75 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 91956.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 881.0 | |
| All* | Total formula weight | 92837.8 |
