5GUP
Cryo-EM structure of mammalian respiratory supercomplex I1III2IV1
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Cytochrome c oxidase subunit 6C | polymer | 73 | 8495.0 | 1 | Sus scrofa (Pig) | ||
| 2 | B | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | polymer | 464 | 50637.8 | 1 | UniProt (F1RVN1) Pfam (PF01512) Pfam (PF10589) UniProt (by SIFTS) (A0A4X1SZP7) In PDB | Sus scrofa (Pig) | |
| 3 | C | NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial | polymer | 463 | 52552.3 | 1 | UniProt (F1S1A8) Pfam (PF00346) In PDB | Sus scrofa (Pig) | |
| 4 | D | NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial | polymer | 264 | 30241.4 | 1 | UniProt (F1SIF2) In PDB | Sus scrofa (Pig) | |
| 5 | E | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial | polymer | 249 | 26301.6 | 1 | UniProt (F1SM98) Pfam (PF01257) In PDB | Sus scrofa (Pig) | |
| 6 | F | NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial | polymer | 123 | 13349.0 | 1 | UniProt (F1S031) Pfam (PF10276) In PDB | Sus scrofa (Pig) | |
| 7 | G | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial | polymer | 727 | 79627.4 | 1 | UniProt (F1SHD7) Pfam (PF13510) Pfam (PF10588) Pfam (PF00384) Pfam (PF09326) UniProt (by SIFTS) (A0A4X1V1H9) In PDB | Sus scrofa (Pig) | |
| 8 | H | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial | polymer | 212 | 23893.3 | 1 | Sus scrofa (Pig) | ||
| 9 | I | NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial | polymer | 216 | 23777.7 | 1 | UniProt (I3LK43) Pfam (PF01058) UniProt (by SIFTS) (A0A8D1TL60) In PDB | Sus scrofa (Pig) | |
| 10 | J | NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial | polymer | 175 | 19718.5 | 1 | UniProt (G8IFA6) Pfam (PF04800) In PDB | Sus scrofa (Pig) | |
| 11 | K, R | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 | polymer | 145 | 17162.4 | 2 | UniProt (F1SQP4) Pfam (PF05071) In PDB | Sus scrofa (Pig) | |
| 12 | L | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial | polymer | 377 | 42606.3 | 1 | UniProt (F1SL07) Pfam (PF01370) In PDB | Sus scrofa (Pig) | |
| 13 | M | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 | polymer | 113 | 12648.6 | 1 | UniProt (F1SA62) In PDB | Sus scrofa (Pig) | |
| 14 | N | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | polymer | 116 | 13321.6 | 1 | UniProt (F1SLY2) In PDB | Sus scrofa (Pig) | |
| 15 | O, X | Acyl carrier protein, mitochondrial | polymer | 156 | 17326.2 | 2 | UniProt (F1SAB6) In PDB | Sus scrofa (Pig) | |
| 16 | P | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 | polymer | 99 | 11099.8 | 1 | UniProt (F1RGE3) Pfam (PF05047) In PDB | Sus scrofa (Pig) | |
| 17 | Q | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 | polymer | 128 | 14953.3 | 1 | UniProt (F1SRG2) In PDB | Sus scrofa (Pig) | |
| 18 | S | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | polymer | 70 | 8088.4 | 1 | UniProt (K7GR43) Pfam (PF15879) In PDB | Sus scrofa (Pig) | |
| 19 | T | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 | polymer | 84 | 9225.6 | 1 | UniProt (F1RNI5) Pfam (PF14987) UniProt (by SIFTS) (A0A4X1VPG4) In PDB | Sus scrofa (Pig) | |
| 20 | U | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial | polymer | 357 | 40476.1 | 1 | UniProt (F1SIS9) Pfam (PF01712) In PDB | Sus scrofa (Pig) | |
| 21 | V | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 | polymer | 141 | 14686.9 | 1 | UniProt (I3LGM4) Pfam (PF02466) In PDB | Sus scrofa (Pig) | |
| 22 | W | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 | polymer | 144 | 16911.6 | 1 | UniProt (F1S6Q1) Pfam (PF06212) UniProt (by SIFTS) (A0A8D1NRT6) In PDB | Sus scrofa (Pig) | |
| 23 | Y | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial | polymer | 105 | 11939.4 | 1 | UniProt (F1SRQ0) In PDB | Sus scrofa (Pig) | |
| 24 | Z | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 | polymer | 98 | 11128.5 | 1 | UniProt (F1SI50) Pfam (PF08122) UniProt (by SIFTS) (A0A4X1VBN1) In PDB | Sus scrofa (Pig) | |
| 25 | a | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial | polymer | 189 | 21587.0 | 1 | UniProt (F1SGC6) Pfam (PF09781) In PDB | Sus scrofa (Pig) | |
| 26 | b | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 | polymer | 128 | 15603.2 | 1 | UniProt (Q2EN80) Pfam (PF09782) In PDB | Sus scrofa (Pig) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 |
| 27 | c | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial | polymer | 186 | 21702.5 | 1 | UniProt (F1RWL7) Pfam (PF05821) In PDB | Sus scrofa (Pig) | Complex I-ASHI,NADH-ubiquinone oxidoreductase ASHI subunit |
| 28 | d | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 | polymer | 176 | 20944.8 | 1 | UniProt (I3LDC3) Pfam (PF10249) In PDB | Sus scrofa (Pig) | |
| 29 | e | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial | polymer | 154 | 17384.7 | 1 | UniProt (F1RWV4) In PDB | Sus scrofa (Pig) | |
| 30 | f | NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial | polymer | 76 | 8630.0 | 1 | UniProt (F1RRC9) Pfam (PF14962) In PDB | Sus scrofa (Pig) | |
| 31 | g | NADH dehydrogenase [ubiquinone] 1 subunit C2 | polymer | 122 | 14327.7 | 1 | UniProt (F1STY1) In PDB | Sus scrofa (Pig) | |
| 32 | h | NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 | polymer | 106 | 12506.6 | 1 | UniProt (F1SV23) Pfam (PF10200) In PDB | Sus scrofa (Pig) | |
| 33 | i | NADH-ubiquinone oxidoreductase chain 2 | polymer | 347 | 39077.5 | 1 | UniProt (O79875) Pfam (PF00361) Pfam (PF06444) In PDB | Sus scrofa (Pig) | NADH dehydrogenase subunit 2 |
| 34 | j | NADH-ubiquinone oxidoreductase chain 3 | polymer | 115 | 12998.4 | 1 | UniProt (O79880) Pfam (PF00507) In PDB | Sus scrofa (Pig) | NADH dehydrogenase subunit 3 |
| 35 | k | NADH-ubiquinone oxidoreductase chain 4L | polymer | 98 | 10827.3 | 1 | UniProt (P56632) Pfam (PF00420) In PDB | Sus scrofa (Pig) | NADH dehydrogenase subunit 4L |
| 36 | l | NADH-ubiquinone oxidoreductase chain 5 | polymer | 606 | 68695.5 | 1 | UniProt (Q9TDR1) Pfam (PF00662) Pfam (PF00361) Pfam (PF06455) In PDB | Sus scrofa (Pig) | NADH dehydrogenase subunit 5 |
| 37 | m | NADH-ubiquinone oxidoreductase chain 6 | polymer | 175 | 19021.3 | 1 | UniProt (O79882) Pfam (PF00499) In PDB | Sus scrofa (Pig) | NADH dehydrogenase subunit 6 |
| 38 | n | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 | polymer | 58 | 7044.3 | 1 | UniProt (F1SD73) Pfam (PF08040) UniProt (by SIFTS) (A0A8D2CGH8) In PDB | Sus scrofa (Pig) | |
| 39 | o | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 | polymer | 129 | 15117.4 | 1 | UniProt (I3LPW0) In PDB | Sus scrofa (Pig) | |
| 40 | p | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 | polymer | 179 | 21864.9 | 1 | UniProt (K7GSE5) Pfam (PF05347) In PDB | Sus scrofa (Pig) | |
| 41 | q | NADH-ubiquinone oxidoreductase chain 4 | polymer | 459 | 51859.4 | 1 | UniProt (O79881) Pfam (PF01059) Pfam (PF00361) In PDB | Sus scrofa (Pig) | NADH dehydrogenase subunit 4 |
| 42 | r | NADH-ubiquinone oxidoreductase chain 1 | polymer | 318 | 35667.5 | 1 | UniProt (O79874) Pfam (PF00146) In PDB | Sus scrofa (Pig) | NADH dehydrogenase subunit 1 |
| 43 | s | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 | polymer | 172 | 20064.1 | 1 | UniProt (F1SLR1) Pfam (PF06747) In PDB | Sus scrofa (Pig) | |
| 44 | t | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 | polymer | 137 | 16487.9 | 1 | Sus scrofa (Pig) | ||
| 45 | u, 5 | Cytochrome b-c1 complex subunit 1, mitochondrial | polymer | 480 | 52756.3 | 2 | UniProt (F1SKM0) Pfam (PF00675) Pfam (PF05193) In PDB | Sus scrofa (Pig) | |
| 46 | v, 6 | Cytochrome b-c1 complex subunit 2, mitochondrial | polymer | 453 | 48264.5 | 2 | Sus scrofa (Pig) | ||
| 47 | w, 7 | Cytochrome b | polymer | 379 | 42840.7 | 2 | UniProt (Q1HBG9) Pfam (PF00032) Pfam (PF00033) In PDB | Sus scrofa (Pig) | |
| 48 | x, 8 | Cytochrome c1, heme protein, mitochondrial | polymer | 326 | 35488.9 | 2 | Sus scrofa (Pig) | ||
| 49 | y, 9 | Cytochrome b-c1 complex subunit 7 | polymer | 111 | 13587.5 | 2 | Sus scrofa (Pig) | ||
| 50 | z, Aa | Cytochrome b-c1 complex subunit 8 | polymer | 82 | 9784.3 | 2 | UniProt (F1RI18) Pfam (PF02939) UniProt (by SIFTS) (A0A4X1UYT9) In PDB | Sus scrofa (Pig) | |
| 51 | 0, Ab | Cytochrome b-c1 complex subunit 6, mitochondrial | polymer | 91 | 10685.8 | 2 | UniProt (F1S3W0) Pfam (PF02320) In PDB | Sus scrofa (Pig) | |
| 52 | 1, Ac | Cytochrome b-c1 complex subunit 9 | polymer | 64 | 7412.5 | 2 | UniProt (Q2EN79) Pfam (PF05365) In PDB | Sus scrofa (Pig) | |
| 53 | 2, 4 | Cytochrome b-c1 complex subunit Rieske, mitochondrial | polymer | 274 | 29492.6 | 2 | UniProt (F1RNZ1) Pfam (PF09165) Pfam (PF02921) Pfam (PF00355) In PDB | Sus scrofa (Pig) | |
| 54 | 3, Ad | Cytochrome b-c1 complex subunit 10 | polymer | 56 | 6560.7 | 2 | UniProt (F1SDI2) Pfam (PF08997) In PDB | Sus scrofa (Pig) | |
| 55 | Ae, Af | Cytochrome b-c1 complex subunit Rieske transit peptide, mitochondrial | polymer | 78 | 7900.1 | 2 | UniProt (F1RNZ1) Pfam (PF09165) In PDB | Sus scrofa (Pig) | |
| 56 | Ag | Cytochrome c oxidase subunit 8B, mitochondrial | polymer | 46 | 4967.8 | 1 | Sus scrofa (Pig) | ||
| 57 | Ah | Cytochrome c oxidase subunit 7A1, mitochondrial | polymer | 59 | 6682.7 | 1 | Sus scrofa (Pig) | ||
| 58 | Ai | Cytochrome c oxidase subunit 7B, mitochondrial | polymer | 56 | 6365.2 | 1 | Sus scrofa (Pig) | ||
| 59 | Aj | Cytochrome c oxidase subunit 7C, mitochondrial | polymer | 47 | 5449.4 | 1 | Sus scrofa (Pig) | ||
| 60 | Ak | Cytochrome c oxidase subunit 1 | polymer | 514 | 57065.8 | 1 | Sus scrofa (Pig) | ||
| 61 | Al | Cytochrome c oxidase subunit 2 | polymer | 227 | 26040.4 | 1 | Sus scrofa (Pig) | ||
| 62 | Am | Cytochrome c oxidase subunit 3 | polymer | 261 | 29943.6 | 1 | Sus scrofa (Pig) | ||
| 63 | An | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | polymer | 147 | 17179.6 | 1 | Sus scrofa (Pig) | ||
| 64 | Ao | Cytochrome c oxidase subunit 5A, mitochondrial | polymer | 109 | 12453.1 | 1 | UniProt (F1SJ34) Pfam (PF02284) In PDB | Sus scrofa (Pig) | |
| 65 | Ap | Cytochrome c oxidase subunit 5B, mitochondrial | polymer | 98 | 10684.0 | 1 | Sus scrofa (Pig) | ||
| 66 | Aq | Cytochrome c oxidase subunit 6A, mitochondrial | polymer | 84 | 9452.7 | 1 | Sus scrofa (Pig) | ||
| 67 | Ar | Cytochrome c oxidase subunit 6B1 | polymer | 85 | 10039.2 | 1 | Sus scrofa (Pig) | ||
| 68 | B, G, H, I | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 6 | Chemie (SF4) | |||
| 69 | B | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 1 | Chemie (FMN) | |||
| 70 | E, G, 2, 4 | FE2/S2 (INORGANIC) CLUSTER | non-polymer | 175.8 | 4 | Chemie (FES) | |||
| 71 | 2, H, 4, V, i | (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL | non-polymer | 767.1 | 5 | Chemie (PLX) | |||
| 72 | L | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 1 | Chemie (NDP) | |||
| 73 | Q, X | S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate | non-polymer | 568.7 | 2 | Chemie (ZMP) | |||
| 74 | x, z, 5, V, 8... | CARDIOLIPIN | non-polymer | 1464.0 | 10 | Chemie (CDL) | |||
| 75 | u, w, 2, 5, 7... | 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine | non-polymer | 749.1 | 10 | Chemie (PEE) | |||
| 76 | w, 7 | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
| 77 | x, 8 | HEME C | non-polymer | 618.5 | 2 | Chemie (HEC) | |||
| 78 | Ak | HEME-A | non-polymer | 852.8 | 2 | Chemie (HEA) | |||
| 79 | Al, Ak | COPPER (II) ION | non-polymer | 63.5 | 3 | Chemie (CU) | |||
| 80 | Ak | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 81 | Ap | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) |
Sequence modifications
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 80 |
| Total formula weight | 1781941.0 | |
| Non-Polymers* | Number of molecules | 52 |
| Total formula weight | 36808.1 | |
| All* | Total formula weight | 1818749.1 |
