5CMK
Crystal structure of the GluK2EM LBD dimer assembly complex with glutamate and LY466195
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Glutamate receptor ionotropic, kainate 2 | polymer | 259 | 29356.6 | 2 | UniProt (P42260) Pfam (PF10613) Pfam (PF00060) In PDB | Rattus norvegicus (Rat) | GluK2,Glutamate receptor 6,GluR6 |
2 | A | GLUTAMIC ACID | non-polymer | 147.1 | 1 | Chemie (GLU) | |||
3 | A, B | LITHIUM ION | non-polymer | 6.9 | 2 | Chemie (LI) | |||
4 | A, B | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
5 | B | (3S,4aR,6S,8aR)-6-{[(2S)-2-carboxy-4,4-difluoropyrrolidin-1-yl]methyl}decahydroisoquinoline-3-carboxylic acid | non-polymer | 346.4 | 1 | Chemie (LY5) | |||
6 | B | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
7 | water | water | 18.0 | 533 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 117 (UniProt: P42260)
A, B: 120 - 259 (UniProt: P42260)
PDB | External Database | Details |
---|---|---|
Gly 1 | - | expression tag |
Thr 91 | Ala 518 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly 118 | - | linker |
Thr 119 | - | linker |
Ser 142 | Ala 689 | engineered mutation |
Ser 174 | Asn 721 | engineered mutation |
Leu 188 | Phe 735 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 58713.2 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 770.4 | |
All* | Total formula weight | 59483.7 |