5AX3
Crystal structure of ERK2 complexed with allosteric and ATP-competitive inhibitors.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Mitogen-activated protein kinase 1 | polymer | 368 | 42231.4 | 1 | UniProt (P28482) Pfam (PF00069) In PDB | Homo sapiens (Human) | MAPK 1,ERT1,Extracellular signal-regulated kinase 2,ERK-2,MAP kinase isoform p42,p42-MAPK,Mitogen-activated protein kinase 2,MAPK 2 |
| 2 | B | allosteric and ATP-competitive inhibitor | polymer | 12 | 1491.8 | 1 | UniProt (by SIFTS) (P40763) In PDB | Homo sapiens | |
| 3 | A | (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL | non-polymer | 392.1 | 1 | Chemie (5ID) |
Sequence modifications
A: -8 - 350 (UniProt: P28482)
| PDB | External Database | Details |
|---|---|---|
| Gly -16 | - | expression tag |
| Asp -15 | - | expression tag |
| Leu -14 | - | expression tag |
| Gly -13 | - | expression tag |
| Ser -12 | - | expression tag |
| Asp -11 | - | expression tag |
| Glu -10 | - | expression tag |
| Leu -9 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 43723.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 392.1 | |
| All* | Total formula weight | 44115.4 |
