4ZZ3

Human GAR transformylase in complex with GAR and pemetrexed

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Trifunctional purine biosynthetic protein adenosine-3	polymer	210	22810.1	1	UniProt (P22102) Pfam (PF00551) In PDB	Homo sapiens (Human)
2	A	N-{4-[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamic acid	non-polymer		425.4	1	Chemie (4DW)
3	A	GLYCINAMIDE RIBONUCLEOTIDE	non-polymer		284.2	1	Chemie (GAR)
4		water	water		18.0	27	Chemie (HOH)

Sequence modifications

A: 808 - 1010 (UniProt: P22102)

PDB	External Database	Details
Met 807	-	initiating methionine
His 1011	-	expression tag
His 1012	-	expression tag
His 1013	-	expression tag
His 1014	-	expression tag
His 1015	-	expression tag
His 1016	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	22810.1
Non-Polymers*	Number of molecules	2
	Total formula weight	709.6
All*	Total formula weight	23519.7

*Water molecules are not included.