4ZO5
PDE10 complexed with 4-isopropoxy-2-(2-(3-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)isoindoline-1,3-dione
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | polymer | 323 | 37430.2 | 2 | UniProt (Q9Y233) In PDB | Homo sapiens (Human) | |
| 2 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | A | 3-(1-hydroxy-2-methylpropan-2-yl)-5-phenyl-3,5-dihydro-1H-imidazo[4,5-c][1,8]naphthyridine-2,4-dione | non-polymer | 350.4 | 1 | Chemie (4PX) | |||
| 5 | B | 2-{2-[3-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-4-(propan-2-yloxy)-1H-isoindole-1,3(2H)-dione | non-polymer | 483.5 | 1 | Chemie (4Q0) | |||
| 6 | water | water | 18.0 | 22 | Chemie (HOH) |
Sequence modifications
A, B: 439 - 759 (UniProt: Q9Y233)
| PDB | External Database | Details |
|---|---|---|
| His 437 | - | expression tag |
| Met 438 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 74860.3 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1013.3 | |
| All* | Total formula weight | 75873.6 |
