4ZJ8
Structures of the human OX1 orexin receptor bound to selective and dual antagonists
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | human OX1R fusion protein to P.abysii glycogen synthase | polymer | 553 | 62685.0 | 1 | UniProt (O43613) UniProt (Q9V2J8) Pfam (PF00001) Pfam (PF13692) In PDB | Homo sapiens (Human) | |
2 | A | [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone | non-polymer | 450.9 | 1 | Chemie (SUV) | |||
3 | A | OLEIC ACID | non-polymer | 282.5 | 6 | Chemie (OLA) | |||
4 | water | water | 18.0 | 18 | Chemie (HOH) |
Sequence modifications
A: 1 - 246 (UniProt: O43613)
A: 1001 - 1196 (UniProt: Q9V2J8)
A: 288 - 380 (UniProt: O43613)
PDB | External Database | Details |
---|---|---|
Asp -7 | - | expression tag |
Tyr -6 | - | expression tag |
Lys -5 | - | expression tag |
Asp -4 | - | expression tag |
Asp -3 | - | expression tag |
Asp -2 | - | expression tag |
Asp -1 | - | expression tag |
Ala 0 | - | expression tag |
A: 288 - 380 (UniProt: O43613)
PDB | External Database | Details |
---|---|---|
Ile 319 | Val 319 | engineered mutation |
His 381 | - | expression tag |
His 382 | - | expression tag |
His 383 | - | expression tag |
His 384 | - | expression tag |
His 385 | - | expression tag |
His 386 | - | expression tag |
His 387 | - | expression tag |
His 388 | - | expression tag |
His 389 | - | expression tag |
His 390 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 62685.0 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 2145.7 | |
All* | Total formula weight | 64830.7 |