4XL4

Crystal structure of thiolase from Clostridium acetobutylicum in complex with CoA

Replaces:  4N46

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Acetyl-CoA acetyltransferase	polymer	400	42345.5	2	UniProt (F0K5D8) Pfam (PF00108) Pfam (PF02803) UniProt (by SIFTS) (A0A0R4I970) In PDB	Clostridium acetobutylicum (strain EA 2018)
2	A, B	COENZYME A	non-polymer		767.5	2	Chemie (COA)
3	A, B	GLYCEROL	non-polymer		92.1	7	Chemie (GOL)
4		water	water		18.0	636	Chemie (HOH)

Sequence modifications

A, B: 1 - 392 (UniProt: F0K5D8)

PDB	External Database	Details
Ser 378	Cys 378	engineered mutation
Leu 393	-	expression tag
Glu 394	-	expression tag
His 395	-	expression tag
His 396	-	expression tag
His 397	-	expression tag
His 398	-	expression tag
His 399	-	expression tag
His 400	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	84691.0
Non-Polymers*	Number of molecules	9
	Total formula weight	2179.7
All*	Total formula weight	86870.7

*Water molecules are not included.