4X5Y
Menin in complex with MI-503
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Menin | polymer | 489 | 54570.2 | 1 | UniProt (O00255) Pfam (PF05053) In PDB | Homo sapiens (Human) | |
| 2 | A | 4-methyl-1-(1H-pyrazol-4-ylmethyl)-5-[(4-{[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino}piperidin-1-yl)methyl]-1H-indole-2-carbonitrile | non-polymer | 564.6 | 1 | Chemie (3XW) | |||
| 3 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 3 | Chemie (DMS) | |||
| 4 | A | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 5 | A | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 6 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 7 | A | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) | |||
| 8 | water | water | 18.0 | 325 | Chemie (HOH) |
Sequence modifications
A: 1 - 459 (UniProt: O00255)
A: 460 - 593 (UniProt: O00255)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| - | Ile 54 | deletion |
| - | Pro 55 | deletion |
| - | Thr 56 | deletion |
| - | Asn 57 | deletion |
| - | Val 58 | deletion |
| - | Pro 59 | deletion |
| - | Glu 60 | deletion |
| - | Leu 61 | deletion |
| - | Thr 62 | deletion |
| - | Phe 63 | deletion |
| - | Gln 64 | deletion |
| - | Pro 65 | deletion |
| - | Ser 66 | deletion |
| - | Pro 67 | deletion |
| - | Ala 68 | deletion |
| - | Pro 69 | deletion |
| - | Asp 70 | deletion |
| - | Pro 71 | deletion |
| - | Pro 72 | deletion |
| - | Gly 73 | deletion |
| - | Glu 387 | deletion |
| - | Glu 388 | deletion |
| - | Arg 389 | deletion |
| - | Pro 390 | deletion |
| - | Gly 391 | deletion |
| - | Glu 392 | deletion |
| - | Gln 393 | deletion |
| - | Ser 394 | deletion |
| - | Gln 395 | deletion |
| - | Gly 396 | deletion |
| - | Thr 397 | deletion |
| - | Gln 398 | deletion |
| Pro 428 | Pro 428 | linker |
| Thr 429 | Thr 429 | linker |
| Pro 430 | Pro 430 | linker |
| Val 431 | Val 431 | linker |
| Leu 432 | Leu 432 | linker |
| His 433 | His 433 | linker |
| Val 434 | Val 434 | linker |
| Gly 435 | Gly 435 | linker |
| Trp 436 | Trp 436 | linker |
| Ala 437 | Ala 437 | linker |
| Thr 438 | Thr 438 | linker |
| Phe 439 | Phe 439 | linker |
| Leu 440 | Leu 440 | linker |
| Val 441 | Val 441 | linker |
| Gln 442 | Gln 442 | linker |
| Ser 443 | Ser 443 | linker |
| Leu 444 | Leu 444 | linker |
| Gly 445 | Gly 445 | linker |
| Arg 446 | Arg 446 | linker |
| Phe 447 | Phe 447 | linker |
| Glu 448 | Glu 448 | linker |
| Gly 449 | Gly 449 | linker |
| Gln 450 | Gln 450 | linker |
| Val 451 | Val 451 | linker |
| Arg 452 | Arg 452 | linker |
| Gln 453 | Gln 453 | linker |
| Lys 454 | Lys 454 | linker |
| Val 455 | Val 455 | linker |
| Arg 456 | Arg 456 | linker |
| Ile 457 | Ile 457 | linker |
| Val 458 | Val 458 | linker |
| Ser 459 | Ser 459 | linker |
| PDB | External Database | Details |
|---|---|---|
| Ala 541 | Thr 541 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 54570.2 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1581.8 | |
| All* | Total formula weight | 56152.0 |
