4X58

Anthranilate phosphoribosyl transferase variant N138A from Mycobacterium tuberculosis in complex with PRPP and Mg

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Anthranilate phosphoribosyltransferase	polymer	378	38805.9	2	UniProt (A5U4M0) Pfam (PF02885) Pfam (PF00591) UniProt (by SIFTS) (P9WFX5) In PDB	Mycobacterium tuberculosis
2	A	D-MALATE	non-polymer		134.1	1	Chemie (MLT)
3	A, B	GLYCEROL	non-polymer		92.1	4	Chemie (GOL)
4	A	1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose	non-polymer		390.1	1	Chemie (PRP)
5	A	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
6	B	IMIDAZOLE	non-polymer		69.1	1	Chemie (IMD)
7		water	water		18.0	274	Chemie (HOH)

Sequence modifications

A, B: 1 - 370 (UniProt: A5U4M0)

PDB	External Database	Details
Leu -7	-	expression tag
Glu -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
Ala 138	Asn 138	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	77611.7
Non-Polymers*	Number of molecules	9
	Total formula weight	1010.2
All*	Total formula weight	78621.9

*Water molecules are not included.