4UM9
Crystal structure of alpha V beta 6 with peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C | Integrin alpha-V heavy chain | polymer | 604 | 66413.5 | 2 | UniProt (P06756) Pfam (PF01839) Pfam (PF08441) In PDB | Homo sapiens (human) | |
| 2 | B | Integrin beta-6 | polymer | 483 | 52989.2 | 1 | UniProt (P18564) Pfam (PF17205) Pfam (PF00362) Pfam (PF18372) In PDB | Homo sapiens (human) | |
| 3 | D | Integrin beta-6 | polymer | 483 | 52962.2 | 1 | UniProt (P18564) Pfam (PF18372) Pfam (PF17205) Pfam (PF00362) In PDB | Homo sapiens (human) | |
| 4 | E, F | Latency-associated peptide | polymer | 13 | 1265.5 | 2 | UniProt (P10600) In PDB | Homo sapiens (human) | LAP |
| 5 | G, J, K, L, M... | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 6 | In PDB GlyTouCan (G42666HT) | |||
| 6 | H | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G22573RC) | |||
| 7 | I, N | alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 2 | In PDB GlyTouCan (G09724ZC) | |||
| 8 | O | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 9 | C, A, B | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 10 | B, C, D, A | CALCIUM ION | non-polymer | 40.1 | 12 | Chemie (CA) | |||
| 11 | D, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 12 | B, C, D | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 8 | Chemie (NAG) | |||
| 13 | C | alpha-D-mannopyranose | non-polymer | 180.2 | 1 | Chemie (MAN) | |||
| 14 | water | water | 18.0 | 230 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 595 (UniProt: P06756)
B: 1 - 474 (UniProt: P18564)
D: 1 - 474 (UniProt: P18564)
E, F: 239 - 249 (UniProt: P10600)
| PDB | External Database | Details |
|---|---|---|
| Cys 400 | Met 430 | conflict |
| Thr 596 | - | expression tag |
| Gly 597 | - | expression tag |
| Gly 598 | - | expression tag |
| Leu 599 | - | expression tag |
| Glu 600 | - | expression tag |
| Val 601 | - | expression tag |
| Leu 602 | - | expression tag |
| Phe 603 | - | expression tag |
| Gln 604 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Cys 270 | Ile 287 | conflict |
| Asn 452 | His 469 | conflict |
| Ser 475 | - | expression tag |
| Arg 476 | - | expression tag |
| Gly 477 | - | expression tag |
| Leu 478 | - | expression tag |
| Gln 479 | - | expression tag |
| Thr 480 | - | expression tag |
| Leu 481 | - | expression tag |
| Phe 482 | - | expression tag |
| Gln 483 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Thr 29 | Gln 46 | conflict |
| Cys 270 | Ile 287 | conflict |
| Asn 452 | His 469 | conflict |
| Ser 475 | - | expression tag |
| Arg 476 | - | expression tag |
| Gly 477 | - | expression tag |
| Leu 478 | - | expression tag |
| Gln 479 | - | expression tag |
| Thr 480 | - | expression tag |
| Leu 481 | - | expression tag |
| Phe 482 | - | expression tag |
| Gln 483 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ace 238 | - | expression tag |
| Nh2 250 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 241309.3 | |
| Branched | Number of molecules | 10 |
| Total formula weight | 6027.6 | |
| Non-Polymers* | Number of molecules | 29 |
| Total formula weight | 3055.7 | |
| All* | Total formula weight | 250392.6 |
