4TUH

Bcl-xL in complex with inhibitor (Compound 10)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E...	Bcl-2-like protein 1	polymer	158	17918.0	8	UniProt (Q07817) Pfam (PF02180) Pfam (PF00452) In PDB	Homo sapiens (Human)	Bcl2-L-1,Apoptosis regulator Bcl-X
2	G, H, A, B, C...	2-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl]-5-{3-[4-(1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenoxy]propyl}-1,3-thiazole-4-carboxylic acid	non-polymer		688.8	8	Chemie (38H)
3	G, H, A, C, F	1,2-ETHANEDIOL	non-polymer		62.1	14	Chemie (EDO)
4	B	ACETATE ION	non-polymer		59.0	1	Chemie (ACT)
5		water	water		18.0	856	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F, G, H: 1 - 26 (UniProt: Q07817)

PDB	External Database	Details
Gly -4	-	expression tag
Pro -3	-	expression tag
Leu -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

A, B, C, D, E, F, G, H: 83 - 209 (UniProt: Q07817)

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	143343.7
Non-Polymers*	Number of molecules	23
	Total formula weight	6438.2
All*	Total formula weight	149781.9

*Water molecules are not included.