4QP7

Crystal Structure of ERK2 in complex with 2-(1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Mitogen-activated protein kinase 1	polymer	369	42548.9	2	UniProt (P28482) Pfam (PF00069) In PDB	Homo sapiens (human)	MAP kinase 1, MAPK 1, ERT1, Extracellular signal-regulated kinase 2, ERK-2, MAP kinase isoform p42, p42-MAPK, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2
2	A, B	2-(1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine	non-polymer		185.2	2	Chemie (363)
3		water	water		18.0	144	Chemie (HOH)

Sequence modifications

A, B: 1 - 360 (UniProt: P28482)

PDB	External Database	Details
Met -8	-	expression tag
Gly -7	-	expression tag
Ser -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	85097.7
Non-Polymers*	Number of molecules	2
	Total formula weight	370.4
All*	Total formula weight	85468.1

*Water molecules are not included.