4QC0
Crystal structure of human TLR8 in complex with XG-1-236
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Toll-like receptor 8 | polymer | 811 | 92835.4 | 2 | UniProt (Q9NR97) Pfam (PF13855) In PDB | Homo sapiens (human) | TLR8 |
2 | C, D, F | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 3 | In PDB GlyTouCan (G15407YE) | |||
3 | E | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G81315DD) | |||
4 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
5 | A, B | 2-butyl-2H-pyrazolo[3,4-c]quinolin-4-amine | non-polymer | 240.3 | 2 | Chemie (XG1) | |||
6 | water | water | 18.0 | 176 | Chemie (HOH) |
Sequence modifications
A, B: 27 - 827 (UniProt: Q9NR97)
PDB | External Database | Details |
---|---|---|
Arg 23 | - | expression tag |
Ser 24 | - | expression tag |
Pro 25 | - | expression tag |
Trp 26 | - | expression tag |
Glu 828 | - | expression tag |
Phe 829 | - | expression tag |
Leu 830 | - | expression tag |
Val 831 | - | expression tag |
Pro 832 | - | expression tag |
Arg 833 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 185670.7 | |
Branched | Number of molecules | 4 |
Total formula weight | 2508.3 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 1586.6 | |
All* | Total formula weight | 189765.7 |