4QA4
Crystal structure of H334R HDAC8 in complex with M344
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Histone deacetylase 8 | polymer | 389 | 43251.0 | 1 | UniProt (Q9BY41) Pfam (PF00850) In PDB | Homo sapiens (human) | HD8 |
2 | A | 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide | non-polymer | 307.4 | 1 | Chemie (B3N) | |||
3 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
4 | A | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) | |||
5 | A | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
6 | water | water | 18.0 | 137 | Chemie (HOH) |
Sequence modifications
A: 1 - 377 (UniProt: Q9BY41)
PDB | External Database | Details |
---|---|---|
Arg 334 | His 334 | engineered mutation |
Ile 378 | - | expression tag |
Glu 379 | - | expression tag |
Gly 380 | - | expression tag |
Arg 381 | - | expression tag |
Gly 382 | - | expression tag |
Ser 383 | - | expression tag |
His 384 | - | expression tag |
His 385 | - | expression tag |
His 386 | - | expression tag |
His 387 | - | expression tag |
His 388 | - | expression tag |
His 389 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 43251.0 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 727.3 | |
All* | Total formula weight | 43978.3 |