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4OBP

MAP4K4 in complex with inhibitor (compound 29), 6-(2-FLUOROPYRIDIN-4-YL)PYRIDO[3,2-D]PYRIMIDIN-4-AMINE

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BMitogen-activated protein kinase kinase kinase kinase 4polymer33237870.12UniProt (O95819)
Pfam (PF00069)
In PDB
Homo sapiens (human)HPK/GCK-like kinase HGK, MAPK/ERK kinase kinase kinase 4, MEK kinase kinase 4, MEKKK 4, Nck-interacting kinase
2AMAGNESIUM IONnon-polymer24.31Chemie (MG)
3A2-(N-MORPHOLINO)-ETHANESULFONIC ACIDnon-polymer195.21Chemie (MES)
4A6-(2-fluoropyridin-4-yl)pyrido[3,2-d]pyrimidin-4-aminenon-polymer241.21Chemie (2QU)
5waterwater18.0321Chemie (HOH)
Sequence modifications
A, B: 2 - 328 (UniProt: O95819)
PDBExternal DatabaseDetails
Gly 0-expression tag
Ser 1-expression tag
Gly 329-expression tag
Asn 330-expression tag
Ser 331-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight75740.2
Non-Polymers*Number of molecules3
Total formula weight460.8
All*Total formula weight76200.9
*Water molecules are not included.

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PDB entries from 2024-06-12

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