4O0V
Back pocket flexibility provides group-II PAK selectivity for type 1 kinase inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Serine/threonine-protein kinase PAK 4 | polymer | 293 | 33068.4 | 1 | UniProt (O96013) Pfam (PF00069) In PDB | Homo sapiens (human) | p21-activated kinase 4, PAK-4 |
| 2 | A | 1-({1-(2-aminopyrimidin-4-yl)-2-[(2-methoxyethyl)amino]-1H-benzimidazol-6-yl}ethynyl)cyclohexanol | non-polymer | 406.5 | 1 | Chemie (2OL) | |||
| 3 | water | water | 18.0 | 10 | Chemie (HOH) |
Sequence modifications
A: 300 - 591 (UniProt: O96013)
| PDB | External Database | Details |
|---|---|---|
| Gly 299 | - | EXPRESSION TAG |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33068.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 406.5 | |
| All* | Total formula weight | 33474.9 |
