4K2P
The Structure of a Quintuple Mutant of the Tiam1 PH-CC-Ex Domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | T-lymphoma invasion and metastasis-inducing protein 1 | polymer | 276 | 31163.9 | 4 | UniProt (Q13009) Pfam (PF00169) Pfam (PF18385) In PDB | Homo sapiens (human) | TIAM-1 |
| 2 | A, B, C, D | CALCIUM ION | non-polymer | 40.1 | 5 | Chemie (CA) | |||
| 3 | water | water | 18.0 | 749 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 429 - 702 (UniProt: Q13009)
| PDB | External Database | Details |
|---|---|---|
| Gly 427 | - | expression tag |
| Ser 428 | - | expression tag |
| Leu 580 | Met 580 | engineered mutation |
| Leu 586 | Met 586 | engineered mutation |
| Ala 596 | Lys 596 | engineered mutation |
| Ala 597 | Lys 597 | engineered mutation |
| Ala 598 | Lys 598 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 124655.4 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 200.4 | |
| All* | Total formula weight | 124855.8 |
