4JZE
Structure of factor VIIA in complex with the inhibitor 2-{2-[(1-aminoisoquinolin-6-yl)carbamoyl]-6-methoxypyridin-3-yl}-5-{[(2S)-1-hydroxy-3,3-dimethylbutan-2-yl]carbamoyl}benzoic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | H | Factor VIIa (Heavy Chain) | polymer | 254 | 28103.3 | 1 | UniProt (P08709) Pfam (PF00089) In PDB | Homo sapiens (human) | Factor VII heavy chain, Activated Factor VIIA Heavy Chain, Coagulation factor VII, Proconvertin, Serum prothrombin conversion accelerator, SPCA |
| 2 | L | Factor VIIa (Light Chain) | polymer | 55 | 6030.8 | 1 | UniProt (P08709) Pfam (PF14670) In PDB | Homo sapiens (human) | Factor VII light chain, Coagulation factor VII, Proconvertin, Serum prothrombin conversion accelerator, SPCA |
| 3 | H | 2-{2-[(1-aminoisoquinolin-6-yl)carbamoyl]-6-methoxypyridin-3-yl}-5-{[(2S)-1-hydroxy-3,3-dimethylbutan-2-yl]carbamoyl}benzoic acid | non-polymer | 557.6 | 1 | Chemie (1NK) | |||
| 4 | H | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 5 | H | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 6 | H | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 7 | water | water | 18.0 | 377 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 34134.1 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1258.2 | |
| All* | Total formula weight | 35392.3 |
