4IKT
Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with N1-(5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)-N2-(5-(trifluoromethyl)pyridin-2-yl)ethane-1,2-diamine
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Methionine aminopeptidase 1 | polymer | 329 | 36935.9 | 1 | UniProt (P53582) Pfam (PF00557) In PDB | Homo sapiens (human) | MAP 1, MetAP 1, Peptidase M 1 |
2 | A | N-[5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl]-N'-[5-(trifluoromethyl)pyridin-2-yl]ethane-1,2-diamine | non-polymer | 408.8 | 1 | Chemie (TFV) | |||
3 | A | COBALT (II) ION | non-polymer | 58.9 | 3 | Chemie (CO) | |||
4 | A | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) | |||
5 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
6 | water | water | 18.0 | 135 | Chemie (HOH) |
Sequence modifications
A: 90 - 393 (UniProt: P53582)
PDB | External Database | Details |
---|---|---|
Met 65 | - | expression tag |
Gly 66 | - | expression tag |
Ser 67 | - | expression tag |
Ser 68 | - | expression tag |
His 69 | - | expression tag |
His 70 | - | expression tag |
His 71 | - | expression tag |
His 72 | - | expression tag |
His 73 | - | expression tag |
His 74 | - | expression tag |
Ser 75 | - | expression tag |
Ser 76 | - | expression tag |
Gly 77 | - | expression tag |
Leu 78 | - | expression tag |
Val 79 | - | expression tag |
Pro 80 | - | expression tag |
Arg 81 | - | expression tag |
Gly 82 | - | expression tag |
Ser 83 | - | expression tag |
His 84 | - | expression tag |
Met 85 | - | expression tag |
Leu 86 | - | expression tag |
Glu 87 | - | expression tag |
Asp 88 | - | expression tag |
Pro 89 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 36935.9 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 716.8 | |
All* | Total formula weight | 37652.7 |