4IHI

Crystal structure of the Delta-pyrroline-5-carboxylate dehydrogenase from Mycobacterium tuberculosis bound with NAD

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Delta-1-pyrroline-5-carboxylate dehydrogenase	polymer	563	61134.6	1	UniProt (O50443) Pfam (PF00171) In PDB	Mycobacterium tuberculosis	PROBABLE PYRROLINE-5-CARBOXYLATE DEHYDROGENASE ROCA
2	A	NICOTINAMIDE-ADENINE-DINUCLEOTIDE	non-polymer		663.4	1	Chemie (NAD)
3		water	water		18.0	450	Chemie (HOH)

Sequence modifications

A: 1 - 543 (UniProt: O50443)

PDB	External Database	Details
Met -19	-	expression tag
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag
Asp 505	Gly 505	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	61134.6
Non-Polymers*	Number of molecules	1
	Total formula weight	663.4
All*	Total formula weight	61798.0

*Water molecules are not included.