4HZ0
Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | DNA topoisomerase 4 subunit B | polymer | 213 | 23864.8 | 2 | UniProt (P20083) Pfam (PF02518) In PDB | Escherichia coli | Topoisomerase IV subunit B |
2 | A, B | 7-(1H-imidazol-1-yl)-2-(pyridin-3-yl)[1,3]thiazolo[5,4-d]pyrimidin-5-amine | non-polymer | 295.3 | 2 | Chemie (1AV) | |||
3 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
4 | water | water | 18.0 | 209 | Chemie (HOH) |
Sequence modifications
A, B: 12 - 216 (UniProt: P20083)
PDB | External Database | Details |
---|---|---|
Leu 217 | - | expression tag |
Glu 218 | - | expression tag |
His 219 | - | expression tag |
His 220 | - | expression tag |
His 221 | - | expression tag |
His 222 | - | expression tag |
His 223 | - | expression tag |
His 224 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 47729.7 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 639.3 | |
All* | Total formula weight | 48368.9 |