4HB0
Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1(K541Q,K542Q,R543S,K545Q,K548Q,K579Q)-Ran-RanBP1
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | GTP-binding nuclear protein Ran | polymer | 216 | 24456.1 | 1 | UniProt (P62826) Pfam (PF00071) In PDB | Homo sapiens (human) | Androgen receptor-associated protein 24, GTPase Ran, Ras-like protein TC4, Ras-related nuclear protein |
2 | B | Ran-specific GTPase-activating protein 1 | polymer | 140 | 16378.8 | 1 | UniProt (P41920) Pfam (PF00638) In PDB | Saccharomyces cerevisiae (yeast) | Chromosome stability protein 20, Perinuclear array-localized protein, Ran-binding protein 1, RANBP1 |
3 | C | Exportin-1 | polymer | 1023 | 117323.5 | 1 | UniProt (P30822) Pfam (PF03810) Pfam (PF08389) Pfam (PF18777) Pfam (PF18784) Pfam (PF18787) Pfam (PF08767) In PDB | Saccharomyces cerevisiae (yeast) | CRM1, Chromosome region maintenance protein 1, Karyopherin-124 |
4 | A | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | non-polymer | 522.2 | 1 | Chemie (GNP) | |||
5 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
6 | C | Leptomycin B | non-polymer | 540.7 | 1 | Chemie (LBF) | |||
7 | C | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
8 | water | water | 18.0 | 790 | Chemie (HOH) |
Sequence modifications
B: 62 - 201 (UniProt: P41920)
C: 1 - 376 (UniProt: P30822)
C: 414 - 1058 (UniProt: P30822)
PDB | External Database | Details |
---|---|---|
Lys 98 | Ala 98 | CONFLICT |
PDB | External Database | Details |
---|---|---|
Gly -1 | - | EXPRESSION TAG |
Ala 0 | - | EXPRESSION TAG |
PDB | External Database | Details |
---|---|---|
Cys 539 | Thr 539 | ENGINEERED MUTATION |
Gln 541 | Lys 541 | ENGINEERED MUTATION |
Gln 542 | Lys 542 | ENGINEERED MUTATION |
Ser 543 | Arg 543 | ENGINEERED MUTATION |
Gln 545 | Lys 545 | ENGINEERED MUTATION |
Gln 548 | Lys 548 | ENGINEERED MUTATION |
Gln 579 | Lys 579 | ENGINEERED MUTATION |
Cys 1022 | Tyr 1022 | ENGINEERED MUTATION |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 158158.4 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 1229.0 | |
All* | Total formula weight | 159387.4 |