4GID
Structure of beta-secretase complexed with inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Beta-secretase 1 | polymer | 388 | 43255.8 | 4 | UniProt (P56817) Pfam (PF00026) In PDB | Homo sapiens (human) | Aspartyl protease 2, ASP2, Asp 2, Beta-site amyloid precursor protein cleaving enzyme 1, Beta-site APP cleaving enzyme 1, Memapsin-2, Membrane-associated aspartic protease 2 |
| 2 | A, B, C, D | N-[(2S)-1-({(2S,3R)-3-hydroxy-1-[(2-methylpropyl)amino]-1-oxobutan-2-yl}amino)-3-phenylpropan-2-yl]-5-[methyl(methylsulfonyl)amino]-N'-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide | non-polymer | 665.8 | 4 | Chemie (0GH) | |||
| 3 | A, B, C, D | L-PROLINAMIDE | non-polymer | 114.1 | 4 | Chemie (LPD) | |||
| 4 | water | water | 18.0 | 1219 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 173023.0 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 3120.0 | |
| All* | Total formula weight | 176143.0 |
