4EAG

Co-crystal structure of an chimeric AMPK core with ATP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	EG:132E8.2 protein	polymer	130	14897.3	1	UniProt (O18645) Pfam (PF16579) In PDB	Drosophila melanogaster (Fruit fly)	FI03728p, SNF1A/AMP-activated protein kinase, SNF1A/AMP-activated protein kinase, isoform A, SNF1A/AMP-activated protein kinase, isoform B, SNF1A/AMP-activated protein kinase, isoform C
2	B	5'-AMP-activated protein kinase subunit beta-1	polymer	85	9794.6	1	UniProt (P80386) Pfam (PF04739) In PDB	Rattus norvegicus (rat)	AMPK subunit beta-1, AMPKb, 5'-AMP-activated protein kinase 40 kDa subunit
3	C	5'-AMP-activated protein kinase subunit gamma-1	polymer	330	37434.1	1	UniProt (P80385) Pfam (PF00571) In PDB	Rattus norvegicus (rat)	AMPK gamma1, AMPK subunit gamma-1, AMPKg
4	C	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	2	Chemie (ATP)
5	C	TRIS(HYDROXYETHYL)AMINOMETHANE	non-polymer		163.2	1	Chemie (TAM)
6		water	water		18.0	81	Chemie (HOH)

Sequence modifications

A: 458 - 582 (UniProt: O18645)

PDB	External Database	Details
Gly 453	-	expression tag
Pro 454	-	expression tag
His 455	-	expression tag
Met 456	-	expression tag
Gly 457	-	expression tag

B: 187 - 270 (UniProt: P80386)

PDB	External Database	Details
Met 186	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	62126.0
Non-Polymers*	Number of molecules	3
	Total formula weight	1177.6
All*	Total formula weight	63303.6

*Water molecules are not included.