4DYY

Crystal Structure of the Cu-adduct of Human H-Ferritin variant MIC1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Ferritin heavy chain	polymer	172	20047.2	1	UniProt (P02794) Pfam (PF00210) In PDB	Homo sapiens (human)	Ferritin H subunit, Cell proliferation-inducing gene 15 protein
2	A	COPPER (II) ION	non-polymer		63.5	3	Chemie (CU)
3	A	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
4	A	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
5	A	2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL	non-polymer		122.1	1	Chemie (TRS)
6		water	water		18.0	164	Chemie (HOH)

Sequence modifications

A: 5 - 176 (UniProt: P02794)

PDB	External Database	Details
Glu 39	Tyr 40	conflict
His 56	Leu 57	engineered mutation
His 63	Arg 64	engineered mutation
His 67	Glu 68	engineered mutation
Glu 74	Asn 75	conflict
Gln 86	Lys 87	engineered mutation
Ala 88	Pro 89	conflict
Glu 90	Cys 91	engineered mutation
Ala 102	Cys 103	engineered mutation
Ala 130	Cys 131	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	20047.2
Non-Polymers*	Number of molecules	7
	Total formula weight	455.0
All*	Total formula weight	20502.2

*Water molecules are not included.