4DTG

Hemostatic effect of a monoclonal antibody mAb 2021 blocking the interaction between FXa and TFPI in a rabbit hemophilia model

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	L	Humanized recombinant FAB fragment, FAB 2021, of a murine antibody, light chain	polymer	219	23846.6	1		Homo sapiens (human)
2	H	Humanized recombinant FAB fragment, FAB 2021, of a murine antibody, heavy chain	polymer	222	23745.4	1		Homo sapiens (human)
3	K	Tissue factor pathway inhibitor	polymer	66	7939.8	1	UniProt (P10646) Pfam (PF00014) In PDB	Homo sapiens (human)	TFPI, Extrinsic pathway inhibitor, EPI, Lipoprotein-associated coagulation inhibitor, LACI
4	L, H	GLYCEROL	non-polymer		92.1	10	Chemie (GOL)
5	H	2-(N-MORPHOLINO)-ETHANESULFONIC ACID	non-polymer		195.2	1	Chemie (MES)
6	H	TRIETHYLENE GLYCOL	non-polymer		150.2	3	Chemie (PGE)
7		water	water		18.0	400	Chemie (HOH)

Sequence modifications

K: 1 - 60 (UniProt: P10646)

PDB	External Database	Details
His 61	-	expression tag
His 62	-	expression tag
His 63	-	expression tag
His 64	-	expression tag
His 65	-	expression tag
His 66	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	55531.8
Non-Polymers*	Number of molecules	14
	Total formula weight	1566.7
All*	Total formula weight	57098.5

*Water molecules are not included.