4DHY

Crystal structure of human glucokinase in complex with glucose and activator

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Glucokinase	polymer	469	52939.1	1	UniProt (P35557) Pfam (PF00349) Pfam (PF03727) In PDB	Homo sapiens (human)	Hexokinase type IV, HK IV, Hexokinase-4, HK4, Hexokinase-D
2	A	alpha-D-glucopyranose	non-polymer		180.2	1	Chemie (GLC)
3	A	N,N-dimethyl-5-({2-methyl-6-[(5-methylpyrazin-2-yl)carbamoyl]-1-benzofuran-4-yl}oxy)pyrimidine-2-carboxamide	non-polymer		432.4	1	Chemie (S41)
4	A	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
5		water	water		18.0	181	Chemie (HOH)

Sequence modifications

A: 12 - 465 (UniProt: P35557)

PDB	External Database	Details
Met -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag
His 2	-	expression tag
His 3	-	expression tag
Glu 4	-	expression tag
Asn 5	-	expression tag
Leu 6	-	expression tag
Tyr 7	-	expression tag
Phe 8	-	expression tag
Gln 9	-	expression tag
Gly 10	-	expression tag
Met 11	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	52939.1
Non-Polymers*	Number of molecules	3
	Total formula weight	635.6
All*	Total formula weight	53574.7

*Water molecules are not included.