4BVC
Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | APOLIPOPROTEIN(A) | polymer | 79 | 9156.1 | 1 | UniProt (P08519) Pfam (PF00051) In PDB | HOMO SAPIENS (HUMAN) | APOLIPOPROTEIN A, APO(A), LP(A) |
| 2 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 3 | A | 3-(4-PIPERIDYL)-N-[2-(TRIFLUOROMETHOXY)PHENYL]SULFONYL-PROPANAMIDE | non-polymer | 380.4 | 1 | Chemie (BV5) | |||
| 4 | A | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 5 | water | water | 18.0 | 110 | Chemie (HOH) |
Sequence modifications
A: 0 - 80 (UniProt: P08519)
| PDB | External Database | Details |
|---|---|---|
| Ala 76 | Asn 4197 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 9156.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 522.0 | |
| All* | Total formula weight | 9678.0 |
