4BSK
Crystal structure of VEGF-C in complex with VEGFR-3 domains D1-2
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 3 | polymer | 214 | 23856.6 | 1 | UniProt (P35916) Pfam (PF21339) In PDB | HOMO SAPIENS (HUMAN) | VEGFR-3, FMS-LIKE TYROSINE KINASE 4, FLT-4, TYROSINE-PROTEIN KINASE RECEPTOR FLT4, VEGFR-3 |
2 | C | VASCULAR ENDOTHELIAL GROWTH FACTOR C | polymer | 121 | 13594.5 | 1 | UniProt (P49767) Pfam (PF00341) In PDB | HOMO SAPIENS (HUMAN) | VEGF-C, FLT4 LIGAND, FLT4-L, VASCULAR ENDOTHELIAL GROWTH FACTOR-RELATED PROTEIN, VRP, VEGF-C |
3 | B | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
4 | A, C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) |
Sequence modifications
A: 23 - 229 (UniProt: P35916)
C: 103 - 215 (UniProt: P49767)
PDB | External Database | Details |
---|---|---|
Ala 230 | - | cloning artifact |
Asp 231 | - | cloning artifact |
Pro 232 | - | cloning artifact |
Ile 233 | - | cloning artifact |
Glu 234 | - | cloning artifact |
Gly 235 | - | cloning artifact |
Arg 236 | - | cloning artifact |
PDB | External Database | Details |
---|---|---|
Asp 101 | - | expression tag |
Pro 102 | - | expression tag |
Ala 137 | Cys 137 | engineered mutation |
His 216 | - | expression tag |
His 217 | - | expression tag |
His 218 | - | expression tag |
His 219 | - | expression tag |
His 220 | - | expression tag |
His 221 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 37451.1 | |
Branched | Number of molecules | 1 |
Total formula weight | 424.4 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 884.8 | |
All* | Total formula weight | 38760.3 |