4AZF

Human DYRK2 in complex with Leucettine L41

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	DYRK2 DUAL-SPECIFICITY TYROSINE-PHOSPHORYLATION REGULATED KINASE 2	polymer	417	48287.4	1	UniProt (Q92630) Pfam (PF00069) In PDB	HOMO SAPIENS (HUMAN)	DYRK2
2	A	5-(1,3-benzodioxol-5-ylmethyl)-2-(phenylamino)-4H-imidazol-4-one	non-polymer		307.3	1	Chemie (3RA)
3	A	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
4	A	PHOSPHATE ION	non-polymer		95.0	1	Chemie (PO4)
5		water	water		18.0	57	Chemie (HOH)

Sequence modifications

A: 73 - 467 (UniProt: Q92630)

PDB	External Database	Details
Met 51	-	expression tag
His 52	-	expression tag
His 53	-	expression tag
His 54	-	expression tag
His 55	-	expression tag
His 56	-	expression tag
His 57	-	expression tag
Ser 58	-	expression tag
Sep 59	-	expression tag
Gly 60	-	expression tag
Val 61	-	expression tag
Asp 62	-	expression tag
Leu 63	-	expression tag
Gly 64	-	expression tag
Thr 65	-	expression tag
Glu 66	-	expression tag
Asn 67	-	expression tag
Leu 68	-	expression tag
Tyr 69	-	expression tag
Phe 70	-	expression tag
Gln 71	-	expression tag
Ser 72	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	48287.4
Non-Polymers*	Number of molecules	3
	Total formula weight	464.3
All*	Total formula weight	48751.7

*Water molecules are not included.