3ZHZ

Structure of Mycobacterium tuberculosis DXR in complex with a fosmidomycin analogue

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE	polymer	397	41599.9	2	UniProt (P64012) Pfam (PF02670) Pfam (PF08436) Pfam (PF13288) UniProt (by SIFTS) (P9WNS1) In PDB	MYCOBACTERIUM TUBERCULOSIS	DXP REDUCTOISOMERASE, 1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERASE, 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE SYNTHASE
2	A	[(1S)-1-(3,4-dichlorophenyl)-3-[oxidanyl-[2-[[3-(trifluoromethyl)phenyl]amino]phenyl]carbonyl-amino]propyl]phosphonic acid	non-polymer		563.3	1	Chemie (FM7)
3		water	water		18.0	191	Chemie (HOH)

Sequence modifications

A, B: 2 - 389 (UniProt: P64012)

PDB	External Database	Details
Met -7	-	expression tag
Ala -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
Val 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	83199.7
Non-Polymers*	Number of molecules	1
	Total formula weight	563.3
All*	Total formula weight	83763.0

*Water molecules are not included.