3WK6

Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Bifunctional epoxide hydrolase 2	polymer	561	63514.5	1	UniProt (P34913) Pfam (PF00702) Pfam (PF00561) In PDB	Homo sapiens (human)	Cytosolic epoxide hydrolase 2, CEH, Epoxide hydratase, Soluble epoxide hydrolase, SEH, Lipid-phosphate phosphatase
2	A	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
3	A	PHOSPHATE ION	non-polymer		95.0	1	Chemie (PO4)
4	A	(5R)-5-methyl-N-(2-phenylethyl)-4,5-dihydro-1,3-thiazol-2-amine	non-polymer		220.3	1	Chemie (S0B)
5		water	water		18.0	155	Chemie (HOH)

Sequence modifications

A: 1 - 555 (UniProt: P34913)

PDB	External Database	Details
His 556	-	expression tag
His 557	-	expression tag
His 558	-	expression tag
His 559	-	expression tag
His 560	-	expression tag
His 561	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	63514.5
Non-Polymers*	Number of molecules	3
	Total formula weight	339.6
All*	Total formula weight	63854.1

*Water molecules are not included.