3WJJ
Crystal structure of IIb selective Fc variant, Fc(P238D), in complex with FcgRIIb
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Ig gamma-1 chain C region | polymer | 230 | 25942.3 | 2 | UniProt (P01857) Pfam (PF07654) In PDB | Homo sapiens (human) | |
2 | C | Low affinity immunoglobulin gamma Fc region receptor II-b | polymer | 179 | 20257.5 | 1 | UniProt (P31994) Pfam (PF13895) In PDB | Homo sapiens (human) | IgG Fc receptor II-b, CDw32, Fc-gamma RII-b, Fc-gamma-RIIb, FcRII-b |
3 | D, E | beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1625.5 | 2 | In PDB GlyTouCan (G33244HE) | |||
4 | water | water | 18.0 | 130 | Chemie (HOH) |
Sequence modifications
A, B: 216 - 445 (UniProt: P01857)
C: 0 - 172 (UniProt: P31994)
PDB | External Database | Details |
---|---|---|
Ser 220 | Cys 103 | engineered mutation |
Asp 238 | Pro 121 | engineered mutation |
PDB | External Database | Details |
---|---|---|
His 173 | - | expression tag |
His 174 | - | expression tag |
His 175 | - | expression tag |
His 176 | - | expression tag |
His 177 | - | expression tag |
His 178 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 72142.0 | |
Branched | Number of molecules | 2 |
Total formula weight | 3251.0 | |
All* | Total formula weight | 75393.0 |